|
KMID : 1137020210320060078
|
|
Journal of Gynecologic Oncology
2021 Volume.32 No. 6 p.78 ~ p.78
|
|
|
Effect of tumor burden and radical surgery on survival difference between upfront, early interval or delayed cytoreductive surgery in ovarian cancer
|
|
Angeles Martina Aida
Cabarrou Bastien
Gil-Moreno Antonio
Perez-Benavente Asuncion
Spagnolo Emanuela
Rychlik Agnieszka
Martinez-Gomez Carlos
Guyon Frederic
Zapardiel Ignacio
Martinez Alejandra
|
|
|
Abstract
|
|
|
Objective: We sought to evaluate the impact on survival of tumor burden and surgical complexity in relation to the number of cycles of neoadjuvant chemotherapy (NACT) in patients with advanced ovarian cancer (OC) with minimal (CC-1) or no residual disease (CC-0).
Methods: This retrospective study included patients with International Federation of Gynaecology and Obstetrics IIIC?IV stage OC who underwent debulking surgery at 4 high-volume institutions between January 2008 and December 2015. We assessed the overall survival (OS) of primary debulking surgery (PDS group), early interval debulking surgery after 3?4 cycles of NACT (early IDS group) and delayed debulking surgery after 6 cycles (DDS group) with CC-0 or CC-1 according to peritoneal cancer index (PCI) and Aletti score.
Results: Five hundred forty-nine women were included: 175 (31.9%) had PDS, 224 (40.8%) early IDS and 150 (27.3%) DDS. Regardless of Aletti score, median OS after PDS was significantly higher than after early IDS or DDS, but the survival difference was higher in women with an Aletti score <8. Among patients with PCI ≤10, median OS after PDS was significantly higher than after early IDS or DDS. In women with PCI >10, there were no differences between PDS and early IDS, but DDS was associated with decreased OS.
Conclusion: The benefit of complete PDS compared with NACT was maximal in patients with a low complexity score. In patients with low tumor burden, there was a survival benefit of PDS over early IDS or DDS. In women with high tumor load, DDS impaired the oncological outcome.
|
|
|
KEYWORD
|
|
|
Ovarian Neoplasms, Fallopian Tube Neoplasms, Peritoneal Neoplasms, Cytoreduction Surgical Procedures, Neoadjuvant Therapy, Tumor Burden
|
|
|
FullTexts / Linksout information
|
|
|
|
|
|
Listed journal information
|
|
    
|